The Multi-Microdose Schedule

**DISCLAIMER** I’ve written these as if we’re hanging out just having a conversation. It is my opinion based on my experience as a scientist and as a part of our commuity. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 

Minimal doses of cannabis or psychedelics spread evenly 3X per day.

Purpose: To describe a dose schedule I have been using for years with cannabis, but only recently extrapolated to mushrooms that allows me to stay at a steady-state that is subtle, maximizes therapeutic benefit, and contributes minimally to tolerance building.

Background: In the pharmaceutical world, a steady-state is reached when the amount of drug in your body stays relatively constant all day. It is a standard dosing procedure used in many different types of medications, but especially mood-stabilizers, antidepressants, and anti-psychotics. It’s very common for prescription medications to be dosed multiple times per day to achieve this. I have found additional benefits from applying this theoretical knowledge to my life…

Protocol: Use your therapeutic minimum (the least amount of any substance you need to receive the main desired effect) 3X per day


      • 8:00AM – 3 hits of a 40/40/20 CBG/CBD/THC blend
      • 2:00PM – 2 hits of 40/40/20 ^^^
      • 8:00PM – 0.5-1g joint of 40/40/20***
*** I wind down with this 0.5-1g dose almost every day regardless of any schedule, but I do add in more THC for different situations (like socializing). 


      • 8:00AM – 0.10 – 0.15g 
      • 2:00PM – 0.10 – 0.15g
      • 8:00PM – 0.15 – 0.3g***

*** The reason I up this last one, because it helps overcome the increase in metabolic enzymes (monoamine oxidase) and feels fairly comparable to me by that point in the day.

NOTE – I rarely combine these two protocols and instead alternate them on a cycle as needed (on my mushroom days I do consume cannabis, but typically only at night as I’m winding down). A 7 day week for me could look like: Monday (cannabis), Tuesday (mushrooms), Wednesday (cannabis), Thursday (mushrooms), Friday (mushrooms or cannabis or nothing), Saturday (ad libitum/no schedule), Sunday (mushrooms or cannabis).

Discussion: I started experimenting with this protocol in late 2018, three whole years after I first introduced CBD into my medical cannabis routine and blasted everything I thought I knew about cannabis wide open. It took three years, because that’s how long it took me to finally feel comfortable understanding how CBD affects THC for me, and could feel confident moving forward without introducing too many other new variables. 

The active molecules that make us feel things each have their own half-life, which is the amount of time it takes for half of the active molecules to be deactivated by our body. The longer the half-life, the longer the molecule will be actively circulating, the longer we will feel the effects.

The half-life of cannabis and mushrooms are both fairly low, meaning they fall below the amount needed to feel the effects after a few hours. Using low doses typically means the half-life is perceivably shorter, because you’re starting off at the threshold of feeling things to begin with.

I would never suggest that anyone try this without the consent and supervision of a medical professional (nurse, MD, DO, PsyD, etc) or therapist who can answer questions on a 1:1 basis. This giant gap in knowledge between scientists and public service workers who keep our society healthy and safe is a huge problem. And it’s a problem we are far too delayed in addressing and why I’m so passionate about sharing my information with everyone, including doctors, therapists, and, yes, even the police and politicians if they are open to learning about how these medicines can be powerful tools to help reduce harm in the community.


7 Responses

  • This is great!! Last weekend I microdosed a mushroom capsule with a gummie then chilled in a hot spring. It was the calmest most at peace feeling I’ve experienced in a long time. I’m not sure the exact dose of either, know it was super low but extremely effective

  • For the past several years I have been on a similar cannabis schedule.

    9:30am: 0.1g 1:1 THC:CBD in vaporizer

    1:00pm: same

    8:00pm 0.1-0.2g

    I have recently been interested in your inclusion of CBG during the day and a reduction of THC. What would you say is the biggest difference in your ratio’s effect?

    MM have also long fascinated me, but up until recently access to quality product has been difficult.

    • For me the biggest effect by far is the amount I trust the medicine (reproducible effects). The CBG/CBD in that high of an amount are both very promiscuous molecules that “buffer” the THC effect. This allows me to keep to a stricter schedule, because I’m not scared that I’m going to get any negative effects or decrease my ability to get my shit done during the day! This then allows me to keep using THC which keeps my CB1 receptor levels lowered. Otherwise before I was in like a see-saw between being able to use it and not feeling comfortable with it…

    • There’s definitely a bit of variability, but in general it’s something like 20% CBD flower 15-18% CBG flower and 20% THC flower. Interestingly, because the THC flower is in the minority, the % doesn’t matter as much (it’s buffered by the CBD/CBG). I’m interested to hear about what you’ve got going on re: potency of your research strains in a couple weeks 🙂

  • Its almost impossible here in the UK to generate and tailor a desired program for one’s self since access to cannabis is largely ‘whatever’ the local dealer has. Id love to be able select strains/concentrations and so on but the UK seems to be for export only.

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